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Updated: Mar 2, 2026

Bioluminescent Optogenetics 2.0: Harnessing Bioluminescence to Activate Photosensory Proteins In Vitro and In Vivo
Published on: August 4, 2021
Visible light initiated release of calcium ions through photochemical electron transfer reactions
Romina R Heymann1, Matthew D Thum, Apryl L Hardee
1Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA. Falvey@umd.edu.
Abstract:
Photolysis of anthraquinone or flavin photosensitizers in the presence of calcium EDTA complexes results in decomposition of the EDTA complex, releasing free Ca2+. In the case of the flavin sensitizers, it is shown that millimolar concentrations of Ca2+ can be released using visible light (>440 nm) and with quantum yields as high as 0.31. The utility of this system is further demonstrated by in situ photogelation of an alginate solution.
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