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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

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As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Related Experiment Video

Updated: Mar 2, 2026

A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
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A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.

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Asthma and early herniated intervertebral disc disease.

Cheng-Di Chiu1,2,3, Hsuan-Ju Chen1,4, Hean-Pat Saw5,6

  • 1a School of Medicine , College of Medicine, China Medical University , Taichung , Taiwan.

Current Medical Research and Opinion
|May 13, 2017
PubMed
Summary

Young asthma patients face a significantly higher risk of developing early herniated intervertebral disc (HIVD) disease. This study highlights a crucial link between asthma and increased susceptibility to spinal conditions in adolescents and young adults.

Keywords:
AgeHIVDadolescentasthmacohort

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Area of Science:

  • Pediatric Spine Health
  • Respiratory Medicine
  • Epidemiology

Background:

  • Herniated intervertebral disc (HIVD) disease in young individuals has complex causes beyond simple disc degeneration.
  • Investigating potential links between asthma and early-onset HIVD is crucial for understanding pediatric spinal health.

Purpose of the Study:

  • To examine the association between asthma and the risk of developing early-onset herniated intervertebral disc (HIVD) disease.
  • To evaluate this risk in a population under 30 years of age.

Main Methods:

  • A retrospective longitudinal cohort study utilized data from Taiwan's National Health Insurance Research Database (NHIRD).
  • 23,470 asthma patients were matched with 23,470 non-asthma patients based on sex, age, and index year.
  • Cox proportional hazards regression analysis assessed HIVD disease risk in asthma patients, adjusting for covariates.

Main Results:

  • Asthma patients demonstrated a 1.69-fold increased risk of HIVD disease compared to non-asthma individuals (95% CI: 1.29-2.23).
  • The asthma group showed elevated risks for both cervical (adjusted HR: 2.38; 95% CI: 1.25-4.57) and lumbar HIVD (adjusted HR: 1.56; 95% CI: 1.15-2.12).

Conclusions:

  • Young individuals with asthma are at a significantly elevated risk for early-onset cervical or lumbar herniated intervertebral disc disease.
  • This finding underscores the importance of considering respiratory health in the context of pediatric spinal conditions.