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Related Experiment Video

Updated: Mar 2, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
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Ranibizumab pretreatment in diabetic vitrectomy: a pilot randomised controlled trial (the RaDiVit study).

O Comyn1, L Wickham1, D G Charteris1

  • 1National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital and University College London (UCL) Institute of Ophthalmology, London, UK.

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Pretreating with intravitreal ranibizumab may improve outcomes for vitrectomy surgery in advanced proliferative diabetic retinopathy by reducing post-operative hemorrhage. A larger study is needed to confirm this modest effect.

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Area of Science:

  • Ophthalmology
  • Retinal Surgery
  • Pharmacological Intervention

Background:

  • Proliferative diabetic retinopathy (PDR) can lead to tractional retinal detachment, often requiring vitrectomy surgery.
  • Assessing adjunctive therapies to improve surgical outcomes in PDR is crucial.

Purpose of the Study:

  • To evaluate the impact of intravitreal ranibizumab pretreatment on vitrectomy outcomes in advanced PDR.
  • To determine the feasibility of a definitive trial and estimate effect size.

Main Methods:

  • Pilot randomized double-masked clinical trial.
  • 30 participants with tractional retinal detachment due to PDR.
  • Intravitreal ranibizumab or subconjunctival saline 7 days before vitrectomy.

Main Results:

  • Ranibizumab group showed a trend towards better visual acuity (52.6 vs 46.7 ETDRS letters).
  • Ranibizumab pretreatment reduced persistent post-operative vitreous cavity hemorrhage (0% vs 2/15 eyes).
  • No significant difference in surgical progression, duration, or difficulty.

Conclusions:

  • Intravitreal ranibizumab pretreatment may reduce post-operative vitreous hemorrhage after vitrectomy for PDR.
  • The observed effect size is modest, necessitating a larger definitive study (estimated 348 subjects per arm).