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Updated: Mar 2, 2026
Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
Published on: May 1, 2012
Fluorogenic Sensing of Carcinogenic Bisphenol A using Aptamer-Capped Mesoporous Silica Nanoparticles
Àngela Ribes1,2, Elena Aznar1,2, Andrea Bernardos1,2
1Instituto Interuniversitario de Investigación de Reconocimiento MolecularyDesarrollo Tecnológico (IDM)., Universitat Politècnica de València, Universitat de València, Camí de Vera s/N, 46022, Valencia, Spain.
Abstract:
Mesoporous silica nanoparticles loaded with rhodamine B and capped with a bisphenol A aptamer were used for the selective and sensitive detection of this lethal chemical. The pores of the nanoparticles are selectively opened in the presence of bisphenol A (through its selective coordination with the aptamer) with subsequent rhodamine B delivery. With this capped material a limit of detection as low as 3.5 μm of bisphenol A was measured.
