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The Lateral Temporal Lobe in Early Human Life
Isabel S Goldstein1, Drexel J Erickson1, Lynn A Sleeper1
1From the Department of Pathology, Boston Children's Hospital and Harvard Medical School (ISG, DJE, RLH, HCK); and Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA (LAS).
Journal of Neuropathology and Experimental Neurology
|May 13, 2017
Summary
This study provides new methods and normative data for analyzing lateral temporal lobe gyrification in infants. These findings aid in understanding brain development and diagnosing temporal lobe pathologies.
Area of Science:
- Neuroscience
- Developmental Biology
- Pediatric Pathology
Background:
- Lateral temporal lobe development abnormalities are linked to various genetic and environmental factors.
- Normative data on temporal lobe gyrification in early life are limited.
- Understanding gyrification patterns is crucial for diagnosing brain abnormalities.
Purpose of the Study:
- To establish guidelines for analyzing lateral temporal lobe gyrification in human infants.
- To present quantitative methods for measuring gyrification using gross brain photographs and computational tools.
- To provide normative ranges for gyrification indices and identify qualitative features.
Main Methods:
- Quantitative analysis of gyrification from gross brain photographs.
- Use of simple computer-based quantitative tools.
- Cohort of 28 brains aged 27–70 postconceptional weeks.
Main Results:
- Normative ranges for temporal lobe gyrification indices were established.
- The ratio of temporal area to whole brain area showed distinct developmental patterns.
- Tertiary gyrification continued linearly through infancy with significant variation.
- Methods demonstrated diagnostic value in cases of gyral disorders.
Conclusions:
- The proposed guidelines and methods are valuable for assessing temporal lobe pathology in pediatric brains.
- This work contributes essential normative data for early life brain development research.
- The findings support the diagnostic utility of quantitative gyrification analysis in clinical settings.
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