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Digit ratio (2D:4D) and postoperative pain perception.

Anna Kasielska-Trojan1, Piotr Stabryła2, Bogusław Antoszewski1

  • 1Plastic, Reconstructive and Aesthetic Surgery Clinic, University Hospital No 1 in Lodz, Lodz, Poland; Plastic, Reconstructive and Aesthetic Surgery Clinic, Institute of Surgery, Medical University of Lodz, Lodz, Poland.

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Prenatal hormone exposure, indicated by digit ratio (2D:4D), influences adult pain perception. Low 2D:4D in women correlates with higher postoperative pain, while in men, it

Keywords:
Digit ratioPostoperative painRhinoplasty

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Area of Science:

  • Endocrinology
  • Pain Perception Research
  • Plastic Surgery

Background:

  • Prenatal sex hormones may influence sex differences in pain perception.
  • Digit ratio (2D:4D) serves as a proxy for prenatal hormone exposure.
  • The link between prenatal hormones and adult pain sensitivity requires further investigation.

Purpose of the Study:

  • To investigate the correlation between the 2D:4D ratio and postoperative pain perception.
  • To explore the influence of prenatal hormone exposure on pain sensitivity after rhinoplasty.

Main Methods:

  • A prospective cohort study of 100 patients (50 women, 50 men) undergoing rhinoplasty.
  • Measurements included digit lengths (for 2D:4D ratio), alongside standard anthropometrics.
  • Postoperative pain was assessed using Visual Analog Scales (VAS) at multiple time points (1h, 6h, 12h, 24h, 48h).

Main Results:

  • Women with a low 2D:4D ratio reported significantly higher pain at 1h and 48h post-operation.
  • In men, a low 2D:4D ratio was associated with lower postoperative pain at 12h.
  • Specific correlations were observed between digit ratio and pain intensity in both sexes.

Conclusions:

  • Low 2D:4D in women is linked to increased postoperative pain.
  • Low right 2D:4D in men is associated with decreased postoperative pain.
  • Findings suggest intrauterine estrogen exposure may enhance pain resistance in women.