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A multicenter feasibility study on ultrafiltration via a single peripheral venous access in acute heart failure with

Marco Morpurgo1, Mario Pasqualini2, Maria Cristiana Brunazzi2

  • 1Centro Cardiologico Monzino, I.R.C.C.S., Milan, Italy.

International Journal of Cardiology
|May 14, 2017
PubMed

Insights

The CHIARA system offers a feasible approach for ultrafiltration in acute heart failure (AHF) patients, removing significant fluid via a single peripheral venous access without major complications.

Area of Science:

  • Cardiology
  • Nephrology
  • Medical Devices

Background:

  • Central venous catheters limit ultrafiltration use in acute heart failure (AHF) with fluid overload.
  • A novel approach is needed to facilitate widespread ultrafiltration in AHF management.

Purpose of the Study:

  • To evaluate the feasibility of the CHIARA system for ultrafiltration using a single peripheral venous cannula.
  • To assess fluid removal efficacy and safety in AHF patients.

Main Methods:

  • A multicenter, prospective feasibility study involving 103 ultrafiltration sessions with the CHIARA device.
  • Treatments involved a single peripheral venous access, lasting ≥6 hours with an ultrafiltration rate ≥100ml/h.
  • Evaluated venous access performance, fluid removed, and interruption causes.

Main Results:

  • Successful completion in 92% of sessions and 80% of patients.
  • Median fluid removal of 3266±3088ml per session (183±30ml/hour).
  • No significant complications related to venous access or anticoagulation.

Conclusions:

  • The CHIARA system demonstrates clinical applicability and efficacy for fluid removal in AHF.
  • A single peripheral venous access is sufficient for effective ultrafiltration.
  • This approach may expand ultrafiltration use in AHF treatment.
Abstract

Keywords:
Acute heart failureCongestive heart failureFeasibility studyUltrafiltration

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