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Related Experiment Videos

c-erbB-2 expression in benign and malignant breast disease.

B A Gusterson1, L G Machin, W J Gullick

  • 1Institute of Cancer Research, Haddow Laboratories, Surrey, UK.

British Journal of Cancer
|October 1, 1988
PubMed
Summary

The c-erbB-2 protein is overexpressed in about 14% of invasive breast cancers, specifically in malignant cells. This overexpression was not linked to lymph node status in this study.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunohistochemistry

Background:

  • The c-erbB-2 protein, a receptor tyrosine kinase, plays a role in cell growth and differentiation.
  • Aberrant expression of c-erbB-2 is implicated in various cancers, including breast cancer.

Purpose of the Study:

  • To investigate the expression of c-erbB-2 protein in breast cancer tissues using a specific antibody.
  • To determine the correlation between c-erbB-2 overexpression and clinicopathological features, such as lymph node involvement.

Main Methods:

  • Immunocytochemical analysis of formalin-fixed paraffin-embedded breast biopsy specimens.
  • Retrospective study of 103 infiltrating ductal carcinomas, 24 pure intraduct carcinomas, and 149 benign breast conditions.

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Main Results:

  • Positive membrane staining for c-erbB-2 was observed in approximately 14% (14/103) of infiltrating ductal carcinomas.
  • c-erbB-2 overexpression was exclusively found in cytologically malignant cells, including in situ components.
  • No correlation was found between c-erbB-2 overexpression and lymph node status in this cohort.

Conclusions:

  • c-erbB-2 protein is overexpressed in a subset of infiltrating ductal carcinomas.
  • The observed c-erbB-2 overexpression is specific to malignant cells.
  • Further investigation into the role of c-erbB-2 in breast cancer pathogenesis is warranted.