Related Experiment Video
Updated: Mar 2, 2026
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
Published on: October 28, 2022
MR imaging for accurate prediction of outcome after perinatal arterial ischemic stroke: Sooner not necessarily better
Nienke Wagenaar1, Niek E van der Aa2, Floris Groenendaal1
1Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands; Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands.
Background:
Involvement of the corticospinal tracts after perinatal arterial ischemic stroke (PAIS) is strongly correlated with adverse motor outcome.
Methods:
Two full-term infants with PAIS, with two early MRI scans available, are reported.
Results:
Diffusion weighted imaging (DWI)-MRI, performed within 24 h following onset of seizures and repeated 48 h later, clearly showed restricted diffusion within the middle cerebral artery territory on both MRIs, but clear patterns of signal intensity changes in the descending corticospinal tracts on the second MRI only.
Conclusion:
Since involvement of the corticospinal tracts is essential for prediction of motor outcome, we may need to reconsider optimal timing of MR imaging for prediction of neurodevelopmental outcome after PAIS.
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