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Related Concept Videos

The Contractile Ring02:15

The Contractile Ring

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Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...
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A Versatile Automated Platform for Micro-scale Cell Stimulation Experiments
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FtsZ-ring Architecture and Its Control by MinCD.

Piotr Szwedziak1, Debnath Ghosal2

  • 1Department of Biology, Institute of Molecular Biology & Biophysics, ETH Zürich, Zürich, Switzerland. piotr.szwedziak@mol.biol.ethz.ch.

Sub-Cellular Biochemistry
|May 14, 2017
PubMed
Summary

Bacterial cell division relies on the FtsZ protein forming a Z-ring. New structural insights into Z-rings and regulatory systems like MinCDE and Noc advance our understanding of this essential cell process.

Keywords:
Bacterial cell divisionCell constrictionCollaborative filamentsCryoETCytomotive filamentsFtsAFtsZLiposome constrictionMinCD copolymersSliding filamentsTomographyZ-ring structure

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Area of Science:

  • Microbiology
  • Cell Biology
  • Structural Biology

Background:

  • The FtsZ protein is a tubulin homologue crucial for bacterial and archaeal cell division, forming the cytokinetic Z-ring.
  • Membrane-tethering proteins (e.g., FtsA, SepF) and regulatory proteins control Z-ring assembly and function.
  • Spatiotemporal regulation of the Z-ring is vital for producing two equal daughter cells.

Purpose of the Study:

  • To advance the understanding of the FtsZ-based cell division mechanism.
  • To elucidate the structural basis of Z-ring formation and regulation.

Main Methods:

  • Visualization of near-atomic structures of Z-rings.
  • Analysis of protein complexes that regulate Z-ring positioning, including MinCDE and Noc systems.

Main Results:

  • Near-atomic structures of Z-rings have been obtained, providing detailed insights into their organization.
  • The mechanisms by which MinCDE and Noc systems negatively regulate FtsZ filaments have been further clarified.
  • Structural data informs mechanistic models of cell division.

Conclusions:

  • Structural visualization has significantly progressed the understanding of bacterial cell division.
  • Regulatory systems like MinCDE and Noc play key roles in controlling Z-ring dynamics.
  • Integrated structural and mechanistic data provide a more comprehensive model for cell division.