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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
[Restorative proctocolectomy for ulcerative colitis : Long-term functional results and quality of life]
E Rijcken1, N Senninger2, R Mennigen2
1Klinik für Allgemein- und Viszeralchirurgie, Universitätsklinikum Münster (UKM), Albert-Schweitzer-Campus 1, Gebäude W1, 48149, Münster, Deutschland. rijcken@uni-muenster.de.
Abstract:
Restorative proctocolectomy with ileo-pouch-anal anastomosis is the standard procedure for ulcerative colitis. It provides complete removal of the diseased colorectum, avoids permanent ileostomy and allows the preservation of continence. Functional results and quality of life after restorative proctocolectomy are of great importance. Patients usually have 5-6 bowel movements per day, and continence is satisfactory in more than 90% of patients. A good pouch function strongly correlates with high quality of life. Postoperative septic complications are the main risk factor for bad pouch function and pouch failure; therefore nowadays most procedures are performed with a covering ileostomy. Quality of life is usually impaired by active ulcerative colitis, and restorative proctocolectomy improves the quality of life up to the level of a healthy reference population. Taken together, restorative proctocolectomy provides excellent results concerning function and quality of life.
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