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Taurine modulates glycine response in Xenopus oocytes injected with messenger RNA from mouse brain
T Horikoshi1, A Asanuma, K Yanagisawa
1Department of Physiology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
Brain Research
|November 1, 1988
Abstract:
The modulatory action of taurine on the glycine response was investigated in Xenopus oocytes injected with messenger RNA from mouse brainstem under voltage-clamped condition. Taurine competitively inhibited the glycine response in a dose-dependent manner. This inhibition was insensitive to bicuculline and intracellularly injected EGTA. The results suggest that taurine could directly modulate glycinergic neurotransmission in the central nervous system.