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Cyclic GMP and protein kinase G inhibit the quantal transmitter release induced by protein kinase C
D D Brănişteanu1, L M Popescu, D D Brănişteanu
1Department of Physiology, Institute of Medicine and Pharmacy, Iassy, Romania.
Brain Research
|November 1, 1988
Abstract:
Protein kinase G inhibits the spontaneous release of acetylcholine quanta at the frog neuromuscular junction as shown by the effects of H-8, a G kinase blocking agent. Moreover, the permeant dibutyryl cGMP blocked the frequency increase obtained in the presence of protein kinase C activators (diacylglycerol and phorbol ester) while the cAMP activated protein kinase A did show only an additive effect.