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A systematic review on potential mechanisms of minocycline in kidney diseases

Hamed Haghi-Aminjan1, Mohammad Hossein Asghari1, Mohammad Hadi Goharbari1

  • 1Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Pharmacological Reports : PR
|May 14, 2017
PubMed

Insights

Minocycline, an antibiotic, shows promise in protecting kidneys by reducing apoptosis, inflammation, and oxidative stress. Further research is needed to confirm its safety and efficacy for treating kidney diseases.

Area of Science:

  • Nephrology
  • Pharmacology
  • Cell Biology

Background:

  • Kidney diseases are a significant cause of mortality requiring specialized care.
  • Minocycline, an antibiotic, exhibits cytoprotective effects beyond its antibacterial properties.
  • Understanding these mechanisms is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To elucidate the cytoprotective mechanisms of minocycline relevant to kidney protection.
  • To systematically review the existing literature on minocycline's effects in renal diseases.

Main Methods:

  • A systematic literature search was conducted in PubMed, Scopus, and Web of Science up to August 2016.
  • Inclusion criteria focused on studies investigating minocycline in renal diseases, regardless of subject (in-vivo/in-vitro, human/animal).
  • PRISMA guidelines were followed for study selection, resulting in the analysis of relevant articles.

Main Results:

  • Key factors in kidney disease progression include apoptosis, oxidative stress, mitochondrial dysfunction, and inflammation.
  • Minocycline demonstrated protective effects through anti-apoptotic, free radical scavenging, anti-inflammatory actions, and modulation of mitochondrial function.
  • Inhibition of matrix metalloproteinase was also identified as a protective mechanism.

Conclusions:

  • Minocycline exhibits significant potential in ameliorating renal malfunctions through multiple cytoprotective pathways.
  • The findings support minocycline as a potential therapeutic agent for kidney diseases.
  • Further investigation into potential adverse effects of minocycline is warranted before clinical application.
Keywords:
ApoptosisMinocyclineMitochondriaOxidative stressSystematic review

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