Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

7.6K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.6K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

15.2K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
15.2K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

11.6K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
11.6K
Abnormal Proliferation02:23

Abnormal Proliferation

5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does Adding a Fissurectomy to Botox Sphincterotomy Increase Success Rate or Just Cost?

The American surgeon·2021
Same author

Evaluation of general surgery residency program websites.

American journal of surgery·2019
Same author

Correction: KSR1 is required for cell cycle reinitiation following DNA damage.

The Journal of biological chemistry·2018
Same author

KSR1 is required for cell cycle reinitiation following DNA damage.

The Journal of biological chemistry·2009
Same author

Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines.

Cancer chemotherapy and pharmacology·2008
Same author

Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity.

Cancer research·2005
Same journal

Social Determinants of Health, Health Disparities, and Surgical Equity.

The Surgical clinics of North America·2026
Same journal

Beyond the Scalpel's Reach.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Society.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Hospitals.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions for Providers.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Patients Social Determinants of Health, Health Disparities, and Surgical Equity.

The Surgical clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Mar 2, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

10.0K

Atypical Colorectal Neoplasms.

Michael G Porter1, Scott M Stoeger1

  • 1Department of Surgery, University of Kansas School of Medicine - Wichita, 929 North St. Francis, Wichita, KS 67214, USA.

The Surgical Clinics of North America
|May 15, 2017
PubMed
Summary
This summary is machine-generated.

Primary colorectal lymphomas, carcinoids, and gastrointestinal stromal tumors are rare cancers. Accurate identification is crucial for effective management, as their treatment differs from standard colorectal adenocarcinoma.

Keywords:
CarcinoidColorectalGISTLymphomaNeuroendocrine

More Related Videos

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

12.8K
In vitro Organoid Culture of Primary Mouse Colon Tumors
07:33

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

36.0K

Related Experiment Videos

Last Updated: Mar 2, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

10.0K
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

12.8K
In vitro Organoid Culture of Primary Mouse Colon Tumors
07:33

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

36.0K

Area of Science:

  • Oncology
  • Gastroenterology
  • Pathology

Background:

  • Colorectal cancers encompass a spectrum of malignancies.
  • Primary colorectal lymphoma, carcinoids (neuroendocrine tumors), and gastrointestinal stromal tumors represent a distinct group.
  • These tumors possess unique biological and clinical characteristics.

Purpose of the Study:

  • To highlight the distinct nature of primary colorectal lymphoma, carcinoids, and gastrointestinal stromal tumors.
  • To emphasize the importance of accurate diagnosis for appropriate patient management.
  • To differentiate these rare colorectal neoplasms from common colorectal adenocarcinoma.

Main Methods:

  • Review of existing literature on primary colorectal lymphoma, carcinoids, and gastrointestinal stromal tumors.
  • Comparative analysis of histopathological features.
  • Discussion of treatment variations based on tumor type.

Main Results:

  • Primary colorectal lymphoma, carcinoids, and gastrointestinal stromal tumors are uncommon malignancies.
  • These tumors exhibit unique pathological and clinical features.
  • Treatment strategies differ significantly from those for colorectal adenocarcinoma.

Conclusions:

  • Accurate identification of primary colorectal lymphoma, carcinoids, and gastrointestinal stromal tumors is essential.
  • Timely and precise diagnosis dictates appropriate therapeutic approaches.
  • Management of these rare colorectal tumors requires specialized consideration distinct from adenocarcinoma.