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Toxicity Testing in Animals

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

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Related Experiment Video

Updated: Mar 2, 2026

Protocol for Acute and Chronic Ecotoxicity Testing of the Turquoise Killifish Nothobranchius furzeri

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Published on: April 24, 2018

Cochleotoxicity monitoring protocol.

José Ferreira Penêda¹, Nuno Barros Lima¹, Leandro Ribeiro¹

¹Department of Otorhinolaryngology, Centro-Hospitalar Vila Nova de Gaia-Espinho, Vila Nova de Gaia, Portugal.

Acta Otorrinolaringologica Espanola

|May 15, 2017

Summary

A proposed cochleotoxicity monitoring protocol aids early detection of hearing damage from platinum compounds or aminoglycoside antibiotics. This vital monitoring is crucial for patient care and preventing underdiagnosis.

Keywords:

Aminoglucósidos Aminoglycosides Audiometry, pure-tone Audiometría, tono puro Compuestos de platino Emisiones otoacústicas.Hearing loss Otoacoustic emissions Platinum compounds Pérdida de la audición

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Area of Science:

Ototoxicology
Clinical Pharmacology
Audiology

Background:

Cochlear damage is a frequent yet underestimated side effect of long-term aminoglycoside therapy and platinum-based chemotherapy.
Early detection of drug-induced cochlear damage is critical, necessitating standardized monitoring protocols in clinical settings.

Purpose of the Study:

To develop a comprehensive monitoring protocol for identifying cochleotoxicity in patients undergoing treatment with platinum compounds or aminoglycoside antibiotics.

Main Methods:

A systematic literature search of the PubMed database was conducted using keywords related to drug-induced cochleotoxicity.
Review of existing articles and clinical guidelines informed the protocol development.

Main Results:

No universal consensus exists for a cochleotoxicity monitoring protocol; implementation varies based on available resources.
High-frequency audiometry and otoacoustic emissions are key diagnostic tools for early detection of aminoglycoside and platinum-induced cochleotoxicity.

Conclusions:

A structured cochleotoxicity monitoring protocol is proposed, encompassing initial patient evaluation, ongoing treatment follow-up, and post-treatment assessment.
Implementation of this protocol can improve the management of patients at risk for hearing loss due to specific drug therapies.