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Peripheral neuropathy associated with angioimmunoblastic lymphadenopathy
I Ferrer1, A Vidaller, A Fernandez de Sevilla
1Departemento de Anatomía Patológica, Hospital Principes de España.
Clinical Neurology and Neurosurgery
|January 1, 1988
Summary
Angioimmunoblastic lymphadenopathy can cause mononeuritis multiplex, a nerve disorder. Nerve biopsies show inflammation and damage similar to lymph node changes in this condition.
Area of Science:
- Neurology
- Immunology
- Pathology
Background:
- Angioimmunoblastic lymphadenopathy (AIBL) is a rare peripheral T-cell lymphoma.
- Mononeuritis multiplex is a neurological condition characterized by damage to multiple individual nerves.
Observation:
- A 49-year-old male presented with mononeuritis multiplex linked to AIBL.
- Sural nerve biopsy revealed myelinated fiber loss, axonal degeneration, and perivascular inflammatory infiltrates.
Findings:
- Inflammatory infiltrates in the nerve consisted of lymphocytes and plasma cells with polyclonal immunoglobulin expression.
- Vascular changes observed included proliferation, wall thickening, and endothelial hyperplasia, mirroring AIBL pathology in lymph nodes and other organs.
Implications:
- This case highlights the potential for AIBL to manifest with significant neurological involvement.
- Understanding these neuropathological changes is crucial for diagnosing and managing patients with AIBL and associated neurological complications.