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Updated: Mar 2, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Acute Heart Failure in the Emergency Department: the SAFE-SIMEU Epidemiological Study
Andrea Fabbri1, Giulio Marchesini2, Giorgio Carbone3
1Department of Emergency Medicine, Morgagni-Pierantoni Hospital, Forlì, Italy.
Italian emergency departments see older acute heart failure (AHF) patients, predominantly female, with multiple comorbidities. This real-world data differs from international registries, highlighting unique patient profiles.
Area of Science:
- Cardiology
- Emergency Medicine
- Public Health
Background:
- Acute heart failure (AHF) patients frequently utilize emergency departments (EDs), contributing to substantial healthcare expenditures.
- Understanding the characteristics of AHF patients in ED settings is crucial for optimizing care and resource allocation.
Purpose of the Study:
- To characterize the clinical profiles of patients presenting to Italian EDs with AHF.
- To analyze the diagnostic and therapeutic management of AHF in these emergency settings.
Main Methods:
- A retrospective analysis of 2683 AHF cases was conducted across six Italian EDs.
- Data collection spanned from January 2011 to June 2012, capturing real-world clinical activity.
Main Results:
- The median patient age was 84 years, with 55.8% females. Over half experienced a first AHF episode.
- Respiratory disease was a primary trigger (approx. 30%), and over 50% had multiple comorbidities (e.g., cardiovascular, pulmonary, renal, diabetes).
- Treatments included oxygen (69.7%), diuretics (69.2%), and noninvasive ventilation (15.2%). In-hospital admission occurred in 60.4%.
Conclusions:
- Italian ED AHF patients are older, more frequently female, and present with higher comorbidity burdens compared to international registry data.
- This study provides critical "real-world" insights into AHF management in Italian emergency departments.
- Findings underscore the need for tailored approaches to AHF care, considering the specific patient demographics and comorbidities observed.
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