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Generation of Alginate Microspheres for Biomedical Applications
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Polyelectrolyte complexes based on alginate/tanfloc: Optimization, characterization and medical application.

Débora P Facchi1, Ana C Lima2, Jean H de Oliveira3

  • 1Postgraduate Program in Environmental Engineering (PPGEA), Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil; Federal University of Technology - Paraná (UTFPR-AP), CEP 86812-460 Apucarana, PR, Brazil.

International Journal of Biological Macromolecules
|May 15, 2017
PubMed
Summary
This summary is machine-generated.

New alginate/tanfloc hydrogels show promise for bone tissue regeneration and antimicrobial applications. These biocompatible scaffolds exhibit excellent cytocompatibility and antibacterial properties against common pathogens.

Keywords:
AlginateBactericidal activityPolyelectrolyte complexScaffoldTannin

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Tanfloc (TN), a cationic biopolymer from tannins, offers potential for biomaterial development.
  • Alginate (AG) is a widely used natural polymer for hydrogel formation.
  • Polyelectrolyte complexes (PECs) offer tunable properties for advanced applications.

Purpose of the Study:

  • To prepare and characterize alginate/tanfloc hydrogels as potential scaffold materials.
  • To evaluate the cytocompatibility and bone regenerative capacity of the developed hydrogels.
  • To assess the antimicrobial and antioxidant activities of the hydrogels and tanfloc.

Main Methods:

  • Preparation of alginate/tanfloc polyelectrolyte complexes (PECs) using a 2^2 factorial design.
  • Characterization using thermal analyses (TGA/DTG, DSC), zeta potential, FTIR, and SEM.
  • In vitro evaluation of cytocompatibility with mouse preosteoblastic cells and antimicrobial assays against S. aureus and E. coli.

Main Results:

  • Optimized alginate/tanfloc PECs were successfully prepared with a rough, porous surface.
  • The AG/TN complex demonstrated outstanding cytocompatibility and promoted bone tissue reconstruction (119% at 10 days).
  • The AG/TN complex exhibited antioxidant and bactericidal activity, while pristine TN showed bacteriostatic/bactericidal effects against S. aureus and E. coli.

Conclusions:

  • Alginate/tanfloc hydrogels are promising biomaterials for bone tissue engineering due to their cytocompatibility and osteogenic potential.
  • Tanfloc and its derived hydrogels possess significant antimicrobial properties, indicating potential for infection control applications.
  • This study introduces tanfloc-based materials for medical applications, highlighting their unexplored potential in regenerative medicine.