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A primer on systematic reviews in toxicology
Sebastian Hoffmann1,2, Rob B M de Vries3, Martin L Stephens1
1Evidence-Based Toxicology Collaboration at Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Archives of Toxicology
|May 15, 2017
Summary
This primer introduces systematic reviews for evidence-based toxicology. It outlines a 10-step process and addresses specific challenges in applying this rigorous method to toxicological questions.
Area of Science:
- Toxicology
- Evidence-based research
- Scientific methodology
Background:
- Systematic reviews offer a transparent, rigorous, and reproducible method for summarizing evidence.
- This approach, well-established in clinical fields, is gaining traction in toxicology.
- Evidence-based toxicology is exploring the adaptation of systematic reviews.
Purpose of the Study:
- To provide a starting point for toxicologists on conducting and understanding systematic reviews.
- To summarize existing guidance documents for systematic reviews from various fields.
- To identify and address specific methodological challenges in applying systematic reviews to toxicology.
Main Methods:
- Summarized available guidance documents on systematic reviews.
- Elaborated on a 10-step systematic review process.
- Identified and discussed specific methodological challenges in toxicology.
Main Results:
- A comprehensive overview of the systematic review process tailored for toxicology.
- Identification of key challenges and proposed solutions for toxicological systematic reviews.
- A framework to guide the application of systematic reviews in toxicology.
Conclusions:
- Systematic reviews are a valuable tool for evidence-based toxicology.
- Addressing specific methodological challenges is crucial for successful adaptation.
- This primer aims to stimulate discussion and foster toxicology-specific methodology.
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