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Celiac Disease and Nonceliac Gluten Sensitivity
Runa D Watkins1, Shamila Zawahir1
1Pediatric Gastroenterology & Nutrition, University of Maryland, 22 South Greene Street, N5W68, Baltimore, MD 21201, USA.
Pediatric Clinics of North America
|May 16, 2017
Summary
Gluten-related disorders like celiac disease (CD), wheat allergy, and nonceliac gluten sensitivity are discussed. Current CD treatment involves a gluten-free diet, with new therapies under investigation.
Area of Science:
- Gastroenterology and Immunology
Background:
- Gluten-related disorders encompass celiac disease (CD), wheat allergy, and nonceliac gluten sensitivity.
- CD is an autoimmune condition damaging the small intestine due to gluten in susceptible individuals.
- Wheat allergy involves immune responses affecting various body systems.
Purpose of the Study:
- To outline the spectrum of gluten-related disorders.
- To describe the pathophysiology of celiac disease.
- To highlight current and emerging treatment strategies for CD.
Main Methods:
- Review of existing literature on gluten-related disorders.
- Analysis of immunological mechanisms in wheat allergy.
- Discussion of diagnostic criteria for nonceliac gluten sensitivity.
Main Results:
- Celiac disease requires a strict gluten-free diet.
- Research is ongoing for alternative CD treatments.
- Nonceliac gluten sensitivity is diagnosed after excluding CD and wheat allergy.
Conclusions:
- Understanding gluten-related disorders is crucial for diagnosis and management.
- The only current treatment for CD is a gluten-free diet.
- Further research is needed for novel therapeutic approaches.
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