Related Experiment Video

Updated: Mar 2, 2026

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice
07:41

Video Imaging and Spatiotemporal Maps to Analyze Gastrointestinal Motility in Mice

Published on: February 3, 2016

14.8K

Motility Disorders in Children

Samuel Nurko1

  • 1Center for Motility and Functional Gastrointestinal Disorders, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02155, USA.

Pediatric Clinics of North America
|May 16, 2017
PubMed

Insights

Pediatric gastrointestinal motility disorders are common, presenting diagnostic challenges. Advances improve understanding and therapy, but further research is crucial for better pediatric GI motility treatments.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Physiology
  • Diagnostic Imaging

Background:

  • Gastrointestinal motility disorders are prevalent in children, varying in severity.
  • Evaluating pediatric GI motility poses unique diagnostic and interpretive challenges.
  • Abnormal motility can be a primary condition or secondary to other diseases.

Purpose of the Study:

  • To review the current understanding of pediatric gastrointestinal motility disorders.
  • To highlight the challenges in performing and interpreting motility evaluations in children.
  • To discuss the impact of recent advances on pathophysiology and therapy.

Main Methods:

  • Review of diagnostic studies including radiographic, scintigraphic, and manometry.
  • Discussion of recent advances in genetics, biology, and technical aspects.
  • Synthesis of current knowledge on pathophysiology and therapeutic approaches.

Main Results:

  • Pediatric GI motility disorders encompass a range of conditions.
  • Diagnostic evaluations require specialized approaches in children.
  • Recent scientific and technical advancements enhance understanding of disease mechanisms.

Conclusions:

  • Despite progress, a deeper understanding of pediatric GI motility pathophysiology is needed.
  • Further research is essential for developing improved therapeutic strategies.
  • Continued investigation will refine diagnostic and treatment protocols for children.

Keywords:
ChildrenHigh-resolution manometryMotility studiesMotor disorders of esophagus

More Related Videos

Gastrointestinal Motility Monitor GIMM08:15

Gastrointestinal Motility Monitor GIMM

Published on: December 1, 2010

31.6K
Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes06:01

Author Spotlight: Reliable and Reproducible In Vitro Assessment of Drug Impact on Rat Intestinal Tubes

Published on: July 26, 2024

1.1K

Related Concept Videos

Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
1.4K
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
1.5K
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
1.1K
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
511
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
1.2K
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
109.7K