Related Experiment Video

Updated: Mar 2, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes
07:54

Isolation of Neonatal Extrahepatic Cholangiocytes

Published on: June 5, 2014

10.9K

Neonatal Cholestasis

Erin Lane1, Karen F Murray1

  • 1Division of Gastroenterology, Seattle Children's Hospital, 4800 Sand Point Way Northeast, M/S OB 9.620, PO Box 50020, Seattle, WA 98115, USA.

Pediatric Clinics of North America
|May 16, 2017
PubMed

Insights

Neonatal jaundice is common, but prolonged or severe cases require evaluation for cholestasis. Early detection and diagnosis of neonatal cholestasis are crucial for timely management.

Area of Science:

  • Neonatology
  • Pediatric Gastroenterology
  • Clinical Pediatrics

Background:

  • Neonatal jaundice is a frequent condition, often benign and related to unconjugated hyperbilirubinemia.
  • Vigilance is required for infants presenting with early-onset, prolonged (over 2 weeks), or high-level jaundice.

Purpose of the Study:

  • To provide an approach for evaluating jaundiced infants.
  • To discuss the diagnosis and management of neonatal cholestasis.

Main Methods:

  • Review of clinical guidelines and literature on neonatal jaundice and cholestasis.
  • Emphasis on fractionated bilirubin testing in specific clinical scenarios.

Main Results:

  • Fractionated bilirubin levels are essential for identifying cholestasis, even in seemingly well infants.
  • Identifies key indicators for further investigation of neonatal jaundice.

Conclusions:

  • A systematic approach aids in differentiating benign jaundice from concerning conditions like cholestasis.
  • Prompt evaluation and diagnosis are vital for effective management of neonatal cholestasis.

Keywords:
Biliary atresiaCholestasisJaundiceNeonatal cholestasisNeonatal liver disease

More Related Videos

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

2.5K
A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

4.3K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
293
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
689
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
411