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Nanostructured lipid carriers employing polyphenols as promising anticancer agents: Quality by design (QbD) approach
Ketki Bhise1, Sushil Kumar Kashaw2, Samaresh Sau1
1Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA.
Abstract:
Cancer is one of the leading causes of death worldwide. There are several hurdles in cancer therapy because of side-effects which limits its usage. Nanoparticulate drug delivery systems have been tested against cancer in a range of scientific studies. In the recent years, advanced research on Nanostructured Lipid Carriers (NLCs) has garnered considerable attention owing to the advantages over their first-generation counterparts, Solid Lipid Nanoparticles (SLN). NLCs facilitate efficient loading of poorly water soluble drugs with simple methods of drug loading. Recently, there is an increased interest in polyphenols because of the evidence of their promising role in prevention of cancer. Polyphenols are produced as secondary metabolites by plants. Their role in prevention of development of tumors through variety of mechanisms and reduction of tumor cell mass has been reported. This article aims to review the science behind development of NLCs and role of polyphenols as promising anticancer agents. Principles of Quality by Design (QbD) have also been explained which are used in formulation-development of many nanoparticles, including NLCs, as reported in literature.
Insights
Nanostructured Lipid Carriers (NLCs) offer advanced cancer therapy by efficiently delivering polyphenols, potent plant-derived anticancer agents. This review explores NLC development and polyphenol efficacy, highlighting Quality by Design (QbD) principles for nanoparticle formulation.
Area of Science:
- Pharmaceutical Sciences
- Nanotechnology
- Oncology
Background:
- Cancer remains a leading global cause of death, with therapy often limited by side effects.
- Nanoparticulate drug delivery systems show promise for cancer treatment.
- Nanostructured Lipid Carriers (NLCs) are advanced systems offering advantages over Solid Lipid Nanoparticles (SLNs), including efficient loading of poorly soluble drugs.
Purpose of the Study:
- To review the scientific principles behind Nanostructured Lipid Carrier (NLC) development.
- To examine the role of polyphenols as promising anticancer agents.
- To explain the application of Quality by Design (QbD) in nanoparticle formulation.
Main Methods:
- Literature review of NLC formulation and characterization.
- Review of studies on polyphenol anticancer mechanisms.
- Discussion of Quality by Design (QbD) principles in nanoparticle development.
Main Results:
- NLCs provide an effective platform for delivering poorly water-soluble drugs, including polyphenols.
- Polyphenols exhibit significant potential in cancer prevention and treatment through various mechanisms.
- Quality by Design (QbD) offers a systematic approach to NLC formulation development.
Conclusions:
- NLCs represent a promising nanocarrier system for enhancing the delivery and efficacy of polyphenol-based anticancer therapies.
- Further research into NLC-polyphenol formulations, guided by QbD, can lead to improved cancer treatments.
- The combination of NLCs and polyphenols holds significant potential for overcoming challenges in cancer therapy.
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