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Reconfigurable Microfluidic Channel with Pin-discretized Sidewalls
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Reconfigurable Microfluidic Channel with Pin-discretized Sidewalls

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Reconfigurable microfluidic device with discretized sidewall.

Masahiro Oono1, Keisuke Yamaguchi2, Amirul Rasyid2

  • 1Department of Mechanical Engineering, Graduate School of Engineering and Science, Shibaura Institute of Technology, 3-7-5 Toyosu, Koto-ku, Tokyo 135-8548, Japan.

Biomicrofluidics
|May 16, 2017
PubMed
Summary
This summary is machine-generated.

Researchers created a reconfigurable microfluidic channel with movable sidewalls. This adaptable design allows for adjustable flow resistance and precise cell manipulation in microfluidic systems.

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Area of Science:

  • Microfluidics
  • Biomedical Engineering
  • Cell Biology

Background:

  • Microfluidic systems utilize features like traps for particle manipulation.
  • Existing microfluidic features can be problematic in subsequent experimental steps requiring different configurations.

Purpose of the Study:

  • To develop a reconfigurable microfluidic channel with adjustable sidewalls.
  • To enable dynamic manipulation of fluidic configurations and cell cultures within microchannels.

Main Methods:

  • Fabrication of a microfluidic channel with mechanically discretized, laterally aligned rectangular pins forming movable sidewalls.
  • Reversible adjustment of channel sidewall positions by sliding pins to alter flow resistance.
  • Application in patterned cell culture and coculture experiments.

Main Results:

  • Flow resistance was reversibly adjusted over a range of 10^1–10^5 Pa·s/μl.
  • Demonstrated patterned culture of COS-7 cells and coculture of endothelial cells (HUVECs) and fibroblasts (hLFs).
  • Sustained COS-7 cell culture in log phase for 216 hours and observed spheroid migration in cocultures.

Conclusions:

  • The developed reconfigurable microfluidic channel offers dynamic control over fluidic environments.
  • This technology facilitates complex cell culture and migration assays within a single microfluidic device.
  • The movable sidewall design provides a versatile platform for advanced microfluidic applications.