Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Design of a triplex fluorescence aptasensor for a culture-free diagnosis of peritoneal dialysis-related peritonitis.

Scientific reports·2026

Same author

A wearable belt for non-invasive monitoring of heart failure parameters.

Sensing and Bio-Sensing Research·2026

Same author

Development of a quality control test for diphtheria vaccine based on an electrochemical aptamer-based biosensor.

Scientific reports·2026

Same author

Corrections to: An aptamer-based fluorometric microcystin-LR assay using DNA strand-based competitive displacement.

Mikrochimica acta·2026

Same author

A Triple-Layer Amniotic Membrane Dressing Drives Robust Wound Healing: In-Depth Protein Profiling and <i>In Vivo</i> Validation in Rat and Human Subjects.

ACS applied bio materials·2026

Same author

A Wearable Microneedle-Integrated Multiplexed Photonic Aptasensor for the Detection of Illicit Drugs in Interstitial Fluid.

Analytical chemistry·2026

Search research articles

Related Experiment Video

Updated: Mar 2, 2026

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

Emerging Loop-Mediated Isothermal Amplification-Based Microchip and Microdevice Technologies for Nucleic Acid

Mohammadali Safavieh¹, Manoj K Kanakasabapathy¹, Farhang Tarlan¹

¹Division of Biomedical Engineering, Division of Renal Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Lansdowne Street, Cambridge, Massachusetts 02139, United States.

ACS Biomaterials Science & Engineering

|May 16, 2017

Summary

Novel loop-mediated isothermal amplification (LAMP) techniques integrated into lab-on-a-chip (LOC) platforms offer rapid, sensitive pathogen detection. These advancements promise to enhance molecular diagnostics, especially in resource-limited settings.

Keywords:

LAMP lab on a chip microfluidics molecular diagnostics nucleic acid tests pathogen detection

More Related Videos

Author Spotlight: Advancing Rapid Detection of Respiratory Pathogens Using Microfluidic Chip

Author Spotlight: Advancing Rapid Detection of Respiratory Pathogens Using Microfluidic Chip

Published on: March 29, 2024

Open-Source Miniature Fluorimeter to Monitor Real-Time Isothermal Nucleic Acid Amplification Reactions in Resource-Limited Settings

Open-Source Miniature Fluorimeter to Monitor Real-Time Isothermal Nucleic Acid Amplification Reactions in Resource-Limited Settings

Published on: February 3, 2021

Related Experiment Videos

Last Updated: Mar 2, 2026

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

Author Spotlight: Advancing Rapid Detection of Respiratory Pathogens Using Microfluidic Chip

Author Spotlight: Advancing Rapid Detection of Respiratory Pathogens Using Microfluidic Chip

Published on: March 29, 2024

Open-Source Miniature Fluorimeter to Monitor Real-Time Isothermal Nucleic Acid Amplification Reactions in Resource-Limited Settings

Open-Source Miniature Fluorimeter to Monitor Real-Time Isothermal Nucleic Acid Amplification Reactions in Resource-Limited Settings

Published on: February 3, 2021

Area of Science:

Molecular Diagnostics
Biotechnology
Point-of-Care Testing

Background:

Accurate pathogen detection is crucial for infectious disease management.
Existing methods like PCR and ELISA are often slow, complex, and costly.
There is a need for accessible, rapid diagnostic tools, particularly in resource-limited areas.

Purpose of the Study:

To review recent advancements in lab-on-a-chip (LOC) diagnostic assays utilizing loop-mediated isothermal amplification (LAMP) for pathogen detection.
To analyze different LOC platform designs for pathogen detection using LAMP.
To discuss the current development and commercialization status of LAMP-based LOC platforms.

Main Methods:

Literature review of novel LAMP-based lab-on-a-chip diagnostic assays.
Analysis of various LOC platform design strategies for pathogen detection.
Discussion of LAMP platforms in development and commercialization.

Main Results:

LAMP-based LOC assays demonstrate significant potential for rapid and sensitive pathogen detection.
Diverse LOC designs are being explored to optimize LAMP performance.
Several LAMP-based LOC platforms are progressing through development and commercialization.

Conclusions:

LAMP-based LOC technology offers a promising solution for revolutionizing molecular diagnostics.
These integrated systems can significantly improve point-of-care testing capabilities.
Further development and commercialization of LAMP-LOC platforms are expected to enhance global infectious disease diagnostics.