GABAB receptors and pain
1Wolfson Centre for Age Related Diseases, King's College London, London SE1 1UL, UK.
None:
Over the past three decades the research on GABAB receptor biology and pharmacology in pain processing has been a fascinating experience. Norman Bowery's fundamental discovery of the existence of the GABAB receptor has led the way to the definition of GABAB molecular mechanisms; patterns of receptor expression in the peripheral and central nervous system; GABAB modulatory functions within the pain pathways. We are now harnessing this acquired knowledge to develop innovative approaches to the therapeutic management of chronic pain through allosteric modulation of the GABAB. Norman's legacy would be ultimately fulfilled by the development of novel analgesics that activate the GABAB receptor. This article is part of the "Special Issue Dedicated to Norman G. Bowery".
Related Concept Videos
Pain
Analgesia and Pain Management
G-protein Coupled Receptors
G-Protein Gated Ion Channels
Sensory...
G Protein-coupled Receptors
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Transducer Mechanism: G Protein–Coupled Receptors
GPCRs are also called heptahelical,...


