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A silencer element from the alpha-globin gene inhibits expression of beta-like genes
G F Atweh1, J M Liu, H E Brickner
1Department of Medicine, University of Michigan School of Medicine, Ann Arbor.
Molecular and Cellular Biology
|November 1, 1988
Abstract:
We have studied the cis and trans interactions of the alpha- and beta-globin genes in a transient expression system. We found that the alpha-globin gene inhibited beta-globin expression in cis but not in trans. The silencer element responsible for this inhibition was localized to a 259-base-pair fragment at the 5' end of the alpha-globin gene.