Related Experiment Video

Updated: Mar 2, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
08:35

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

4.3K

Resistant hypertension in 2017

Sartaj Hans1, John P Reilly

  • 1Department of Cardiovascular Diseases, The John Ochsner Heart and Vascular Institute, The Ochsner Clinical School, University of Queensland, Ochsner Medical Center, New Orleans, Louisiana, USA.

Current Opinion in Cardiology
|May 16, 2017
PubMed

Insights

Resistant hypertension (HTN) affects many patients, with newer endovascular treatments like renal denervation showing promise. A combined approach of lifestyle changes, medication, and tailored procedures may offer new hope for managing this condition.

Area of Science:

  • Cardiology and Nephrology
  • Interventional Cardiology
  • Hypertension Research

Background:

  • Hypertension (HTN) is a widespread condition contributing significantly to morbidity and mortality.
  • Resistant HTN, defined as blood pressure above 140/90 mmHg despite three medications, affects up to half of HTN patients in the U.S.
  • The prevalence of HTN and resistant HTN is increasing, necessitating novel therapeutic strategies to improve patient compliance and reduce adverse events.

Purpose of the Study:

  • To review recent advancements in endovascular therapies for resistant hypertension.
  • To explore novel techniques such as renal denervation and endovascular carotid body stimulation.
  • To discuss the role of revascularization in renovascular hypertension.

Main Methods:

  • Review of recent studies on renal denervation technologies, including multipolar electrodes.
  • Examination of early experiences with noninvasive renal denervation.
  • Analysis of endovascular carotid body stimulation investigations.
  • Assessment of revascularization outcomes for renovascular hypertension.

Main Results:

  • Renal denervation technologies, from original trials to newer electrodes, are summarized.
  • Early data on noninvasive renal denervation and endovascular carotid body stimulation are presented.
  • Renovascular hypertension may be effectively treated by revascularization in select patients.

Conclusions:

  • A comprehensive strategy involving lifestyle modification, pharmacologic therapy, and endovascular treatments is proposed for resistant HTN.
  • Most endovascular treatments require further validation.
  • Recent studies have cast doubt on the efficacy of renal revascularization for renovascular HTN when not precisely targeted.
Abstract

More Related Videos

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension04:37

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

803
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

8.1K

Related Concept Videos

Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
1.1K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.6K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.2K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
686
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
554
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
792