Related Experiment Video

Updated: Mar 2, 2026

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.4K

MYC-Master Regulator of the Cancer Epigenome and Transcriptome

Candace J Poole1, Jan van Riggelen2

  • 1Augusta University, Department of Biochemistry and Molecular Biology, 1410 Laney-Walker Blvd., Augusta, GA 30912, USA. capoole@augusta.edu.

Genes
|May 16, 2017
PubMed

Insights

The MYC oncogene, often overexpressed in cancers, functions beyond traditional transcription factor roles. It actively regulates the cancer epigenome and transcriptome, offering new therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Overexpression of the MYC oncogene is a common feature in many human cancers.
  • MYC has traditionally been viewed as a transcription factor that deregulates target gene expression.
  • Existing models face challenges due to modest effects on target genes and cell-type-specific regulation.

Purpose of the Study:

  • To review MYC's role as a regulator of the cancer epigenome and transcriptome.
  • To explore MYC's mechanisms in regulating chromatin structure.
  • To discuss implications for cancer therapeutics.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of MYC's genome-wide and site-specific chromatin regulation.
  • Synthesis of findings related to MYC's non-traditional functions.

Main Results:

  • MYC's function extends beyond sequence-specific transcription.
  • MYC actively influences chromatin structure at specific sites and genome-wide.
  • These regulatory roles present new avenues for therapeutic intervention.

Conclusions:

  • MYC's epigenetic and transcriptomic regulatory functions are critical in cancer.
  • Understanding these broader roles is essential for developing effective cancer therapies.
  • Targeting MYC's epigenetic influence may overcome limitations of traditional approaches.
Keywords:
MYCcancerchromatin remodeling

More Related Videos

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.9K
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

7.0K

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.9K
Master Transcription Regulators02:23

Master Transcription Regulators

2.8K
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.1K
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.0K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.7K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K