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Updated: Mar 2, 2026

Temporal Analysis of the Nuclear-to-cytoplasmic Translocation of a Herpes Simplex Virus 1 Protein by Immunofluorescent Confocal Microscopy
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The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

Richard B Tunnicliffe1, Michael P Lockhart-Cairns2,3, Colin Levy1

  • 1Manchester Institute of Biotechnology, School of Chemistry, Faculty of Science and Engineering, The University of Manchester, Manchester M1 7DN, UK.

Nucleic Acids Research
|May 16, 2017
PubMed
Summary

Herpes simplex virus ICP4 protein uses a novel homo-dimeric fold and an intrinsically disordered region to bind DNA. This dual recognition mechanism enhances viral gene expression and infection control.

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