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Updated: Mar 2, 2026
Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
Standardization of the apparent diffusion coefficient value of bladder cancer across different centers: Applicability
Toshinori Nishizawa1, Soichiro Yoshida1, Fumitaka Koga2
1Department of Urology, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Purpose:
We investigated whether the standardized apparent diffusion coefficient (ADC) value reflects bladder cancer characteristics across different centers.
Methods:
Ninety-eight bladder cancer patients underwent MRI at two institutions. Standardized tumor ADC (sT-ADC) was calculated by dividing absolute tumor ADC (aT-ADC) by that of gluteus maximus. We compared ADCs between MRI protocols according to grade and T-stage.
Results:
The differences in aT-ADC between MRI protocols were negated by sT-ADC. The best sT-ADC cut-offs to predict cancer aggressiveness in the development cohort worked in the validation cohort compared to the development cohort.
Conclusion:
Standardized ADC overcomes the incompatibility between different MRI protocols.
