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Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
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Novel Insights in Fetal Cardiomyopathy due to in utero Herpes Simplex Virus Infection

Tamara Margit Jutta Pahlitzsch1, Elisa Theresa Helbig, Nanette Sarioglu

  • 1Department of Obstetrics, Charité Universitätsmedizin Berlin, Berlin, Germany.

Fetal Diagnosis and Therapy
|May 16, 2017
PubMed

This is a case report of fatal cardiomyopathy in a fetus following maternal intrauterine infection with herpes simplex virus (HSV), despite the mother having no symptoms of an infection. The fetus showed signs of a disseminated infection affecting the heart, brain, lungs, liver, adrenal glands, and skin. HSV cardiomyopathy, characterized by vast necrosis, extensive calcifications, and inflammatory infiltration, was found to be the cause of intrauterine fetal death. To our knowledge, this is a unique report of an asymptomatic maternal nonprimary or recurrent HSV infection that induced a transmission of HSV resulting in extensive and fatal changes in the fetal heart.

Keywords:
Fetal cardiomyopathyHerpes simplex virusPrenatal diagnosisSonography

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