Related Experiment Video

Updated: Mar 2, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

2.2K

[Novel Adjuvant Therapy for Ocular Melanoma]

Jacobus J Bosch1, Ludwig M Heindl2

  • 1Medizinische Klinik 5, Hämatologie und internistische Onkologie, Universitatsklinikum Erlangen.

Klinische Monatsblatter Fur Augenheilkunde
|May 16, 2017
PubMed

Insights

Malignant melanoma of the eye lacks effective metastatic therapies. Targeting tumor lymphangiogenesis and immune cell infiltration offers promising new avenues for adjuvant treatment strategies.

Area of Science:

  • Ophthalmology
  • Oncology
  • Immunology

Background:

  • Malignant melanoma is the most common adult eye cancer, originating in the uveal tract or conjunctiva.
  • While primary tumors are treatable, metastatic conjunctival and uveal melanoma lack effective therapies.
  • Tumor-associated lymphangiogenesis and immune cell infiltration are critical in melanoma metastasis and therapeutic targeting.

Purpose of the Study:

  • To review translational research on lymphangiogenesis and its inhibition in ocular melanoma.
  • To explore immune cell infiltration modulation via immunotherapy for eye melanoma.
  • To summarize research on lymphangiogenesis and immune cells in ocular melanoma within the FOR 2240 clinical research unit.

Main Methods:

  • Review of current translational research literature.
  • Analysis of previous and ongoing studies on ocular melanoma.
  • Focus on lymphangiogenesis and immune cell dynamics.

Main Results:

  • Lymphangiogenesis and immune cell infiltration are key factors in ocular melanoma.
  • Therapeutic inhibition of lymphangiogenesis is under investigation.
  • Immunotherapy approaches (passive and active) are being explored to modulate immune cell infiltration.

Conclusions:

  • Modulating tumor-associated lymphangiogenesis presents a potential therapeutic target.
  • Targeting immune cell infiltration could lead to novel adjuvant therapies for eye melanoma.
  • Translational research is crucial for developing new treatment strategies for metastatic ocular melanoma.

More Related Videos

Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development06:46

Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development

Published on: September 4, 2021

1.9K
Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

4.1K

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.4K
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
103
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K