On the antigen-antibody interaction: A thermodynamic consideration
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Updated: Mar 2, 2026

Rapid Determination of Antibody-Antigen Affinity by Mass Photometry
Published on: February 8, 2021
Abstract:
Despite its relevance to many biomedical fields, relatively little effort has been put into a comprehensible quantitative description of the effect of reaction temperature on the interaction between antigens and their antibodies. In this article, a novel, straightforward mathematical model is proposed, which aims to describe the effect of temperature on antigen-antibody kinetics. The model proposed in this article could hopefully provide clinicians, immunologists, and biochemists with an improved insight into the kinetic effect of fluctuations in reaction temperature on antigen-antibody-dependent processes and therefore into the kinetics of the humoral adaptive immune response.
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