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Lipid Peroxidation Markers in Coronary Artery Disease Patients with Possible Vascular Mild Cognitive Impairment

Ivonne Suridjan1, Nathan Herrmann1, Alex Adibfar2

  • 1Hurvitz Brain Sciences Program, Sunnybrook Research Institute and Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Journal of Alzheimer'S Disease : JAD
|May 17, 2017
PubMed

Insights

Lower lipid peroxidation, a marker of oxidative stress, is linked to better cognitive gains from exercise in coronary artery disease patients at risk for dementia. Elevated levels may hinder exercise benefits.

Area of Science:

  • Biomarkers
  • Neuroscience
  • Cardiology

Background:

  • Coronary artery disease (CAD) patients are at increased risk for dementia.
  • Lipid peroxidation, a marker of oxidative stress, plays a role in vascular damage and cognitive decline.
  • Understanding the relationship between lipid peroxidation and cognitive function is crucial for developing interventions.

Purpose of the Study:

  • To investigate the association between lipid peroxidation markers and cognitive function in adults with CAD.
  • To examine how these markers influence cognitive response to a 24-week exercise intervention program.
  • To determine if lipid peroxidation can serve as a biomarker for early vascular cognitive impairment.

Main Methods:

  • Serum samples from 118 patients (29 with possible vascular mild cognitive impairment, 89 controls) were analyzed for lipid peroxidation products.
  • Ratios of early-stage (lipid hydroperoxides, LPH) to late-stage (8-isoprostane, 8-ISO; 4-hydroxy-2-nonenal, 4-HNE) products were calculated.
  • Cognitive performance was assessed before and after the 24-week exercise intervention.

Main Results:

  • A significant group effect on lipid peroxidation markers was observed after adjusting for covariates.
  • Lower baseline 8-isoprostane (8-ISO) concentration was associated with greater improvements in verbal memory and executive function.
  • Higher ratios of late-stage to early-stage lipid peroxidation products (8-ISO/LPH and (8-ISO+4-HNE)/LPH) correlated with less improvement in executive function post-intervention.

Conclusions:

  • Lipid peroxidation may serve as an early biomarker for vascular cognitive impairment in CAD patients.
  • Elevated lipid peroxidation levels might impede the cognitive benefits derived from exercise interventions in this population.
  • Targeting lipid peroxidation could be a strategy to enhance cognitive outcomes in individuals with CAD at risk for dementia.

Keywords:
Cardiovascularcoronary artery diseaseexerciseheart diseasehydroperoxidehydroxynonenalisoprostanelipid peroxidationoxidative stressvascular cognitive impairment

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