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Updated: Mar 2, 2026

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Interstitial pneumonia pattern on day 7 chest radiograph predicts bronchopulmonary dysplasia in preterm infants

Hye-Rim Kim1,2,3, Ji Young Kim4, Bo La Yun4

  • 1Department of Pediatrics, Bundang CHA Medical Center, CHA University, Seongnam, Republic of Korea.

BMC Pediatrics
|May 17, 2017
PubMed

Insights

Early chest X-rays showing interstitial pneumonia in preterm infants can identify those at high risk for bronchopulmonary dysplasia (BPD) or death. This allows for targeted interventions to improve outcomes for vulnerable newborns.

Area of Science:

  • Neonatology
  • Pediatric Radiology
  • Respiratory Medicine

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant complication in preterm infants.
  • Early identification of infants at risk for BPD is crucial for timely intervention.
  • Current methods for risk stratification may not be sufficiently precise.

Purpose of the Study:

  • To evaluate if the interstitial pneumonia pattern on day 7 chest radiographs predicts BPD or death before 36 weeks postmenstrual age (PMA).
  • To assess the utility of early radiographic findings in identifying high-risk preterm infants.

Main Methods:

  • Retrospective cohort study of 336 preterm infants (birth weight < 1500g, GA < 32 weeks).
  • Day 7 chest radiographs reviewed by two independent pediatric radiologists.
  • Analysis of data from 304 infants surviving > 7 days.

Main Results:

  • Interstitial pneumonia pattern on day 7 chest radiograph was associated with BPD or death before 36 weeks PMA (OR 4.0).
  • This pattern demonstrated high specificity (98%) in predicting BPD or death.
  • Histologic chorioamnionitis was a preceding factor associated with the interstitial pneumonia pattern (OR 3.7).

Conclusions:

  • The interstitial pneumonia pattern on day 7 chest radiographs is a specific predictor of BPD or death in preterm infants.
  • This finding can guide the selection of high-risk infants for preventive interventions.
  • Early radiographic assessment aids in targeted management strategies for BPD.
Abstract

Keywords:
Bronchopulmonary dysplasiaChest radiographInterstitial pneumoniaPredictor

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