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Related Concept Videos

Overview of Protein Metabolism01:21

Overview of Protein Metabolism

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Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
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Chronic Kidney Disease III: Interprofessional Care01:28

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Proteins: Dietary Sources and Requirements01:28

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Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Protein Absorption01:12

Protein Absorption

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Proteins in the gastrointestinal tract typically come from food, but they can also originate from disintegrated cells or secreted enzymes. In the stomach, the enzyme pepsin breaks down these proteins into polypeptides. The fragments then move into the duodenum as a semi-fluid mass called chyme. Pancreatic proteases, such as trypsin and chymotrypsin, and intestinal brush border enzymes like carboxypeptidases further dismantle the polypeptides into tripeptides, dipeptides, and free amino acids.
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Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
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High protein intake without concerns?

Olav Rooyackers1,2, Martin Sundström Rehal1,2, Felix Liebau1,2

  • 1Department of Anesthesia and Intensive Care Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden.

Critical Care (London, England)
|May 17, 2017
PubMed
Summary
This summary is machine-generated.

Current trends suggest increasing protein intake for critically ill patients, but evidence is lacking. Sticking to established European Society for Clinical Nutrition and Metabolism (ESPEN) guidelines of 1.2-1.5 g/kg/day for protein may be more beneficial.

Keywords:
Critical careNitrogen balanceProtein balanceProtein intakeProtein turnover

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Area of Science:

  • Critical Care Medicine
  • Nutritional Science
  • Clinical Nutrition

Background:

  • High protein intake is a current trend in nutrition for critically ill patients.
  • Several opinion leaders advocate for increased protein recommendations.
  • There is a lack of new evidence supporting these elevated recommendations.

Purpose of the Study:

  • To evaluate the trend of increasing protein recommendations in critically ill patients.
  • To assess the evidence supporting higher protein intake.
  • To argue for adherence to existing guidelines.

Main Methods:

  • Review of current trends and opinion leader recommendations.
  • Analysis of existing evidence regarding protein intake in critically ill patients.
  • Comparison of recommended versus actual protein intake in clinical practice.

Main Results:

  • Protein intake in clinical practice is often below current European Society for Clinical Nutrition and Metabolism (ESPEN) recommendations (1.2-1.5 g/kg/day).
  • No new evidence supports the upward expansion of suggested protein allowances.
  • Observational data indicate a gap between recommended and actual protein intake.

Conclusions:

  • Adhering to current ESPEN guidelines for protein intake (1.2-1.5 g/kg/day) may be in the best interest of critically ill patients.
  • There is a need for a conservative approach to protein recommendations, avoiding upward stretching without new supporting evidence.
  • Further research is needed to clarify optimal protein intake in critical illness.