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The Thyroid Gland

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Radioguided thyroidectomy for follicular tumors: Multicentric experience.

D Parmeggiani¹, C Gambardella², R Patrone²

¹Unit of Surgery, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples (SUN), Naples, Italy.

International Journal of Surgery (London, England)

|May 17, 2017

Summary

This summary is machine-generated.

Sestamibi scintigraphy aids in diagnosing thyroid nodules, distinguishing benign from malignant follicular lesions. Intraoperative use of sestamibi (MIBI) scintigraphy improves surgical guidance for thyroidectomies.

Keywords:

99m Tc-MIBI scintigraphy MIBI uptake Radioguided surgery Thyroid cancer Thyroid follicular neoplasm Thyroidectomy

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Area of Science:

Nuclear medicine imaging
Endocrine surgery
Oncology

Background:

Thyroid nodular diseases require integrated diagnostics, including ultrasonography, scintigraphy, and fine needle aspiration biopsy (FNAB).
FNAB can be inconclusive for "Follicular Lesions," necessitating surgery for definitive diagnosis.
The study evaluates scintigraphy's role in preoperative and intraoperative thyroid nodule assessment.

Purpose of the Study:

To assess the utility of sestamibi scintigraphy in the preoperative diagnosis of thyroid nodules.
To evaluate sestamibi scintigraphy as an intraoperative tool for guiding surgical excision extent.
To differentiate between benign and malignant follicular thyroid lesions using scintigraphy.

Main Methods:

A retrospective analysis of 360 follicular neoplasms from 4482 thyroidectomies.
Preoperative 99mTc-sestaMIBI scintigraphy with early and late imaging, compared with 99mTc-pertechnetate subtraction.
Intraoperative use of a surgical probe (Neoprobe) to quantify sestamibi uptake in selected nodules.

Main Results:

Follicular carcinomas demonstrated high preoperative and intraoperative sestamibi uptake.
Benign nodules showed low intraoperative uptake, while follicular adenomas had moderate uptake.
Papillary carcinomas exhibited only mild sestamibi uptake.

Conclusions:

Preoperative sestamibi scintigraphy enhances diagnostic information for thyroid nodules.
Intraoperative sestamibi scintigraphy accurately identifies high-risk nodules.
Radio-guided surgery using sestamibi shows promise for treating thyroid follicular lesions.