Bombesin administration impairs memory and does not reverse memory deficit caused by sleep deprivation
L B T Ferreira1, S L B Oliveira1, J Raya1
1Psychobiology Department, Universidade Federal de São Paulo, São Paulo, Brazil.
Behavioural Brain Research
|May 17, 2017
Summary
Sleep deprivation impairs memory. Bombesin (a GRP agonist) did not prevent this impairment in rats and actually hindered memory consolidation under normal conditions, suggesting it
Area of Science:
- Neuroscience
- Behavioral Neuroscience
- Pharmacology
Background:
- Sleep deprivation negatively impacts emotional memory performance.
- Neuropeptides like Gastrin Releasing Peptide (GRP) may regulate memory processes.
- GRP's role in sleep deprivation-induced memory deficits requires further investigation.
Purpose of the Study:
- To investigate the effect of Bombesin (BB), a GRP agonist, on memory performance in sleep-deprived Wistar rats.
- To determine if BB administration can mitigate memory impairments caused by sleep loss.
- To assess BB's impact on memory consolidation under normal sleep conditions.
Main Methods:
- Wistar rats were subjected to sleep deprivation using the modified multiple platforms method (MMPM).
- Intraperitoneal (IP) administration of varying doses of BB (2.5, 5.0, 10.0μg/kg) was performed.
- Memory performance was evaluated using a multiple trial inhibitory avoidance (MTIA) task, assessing acquisition and retention.
Main Results:
- Sleep-deprived rats showed significant impairment in both memory acquisition and retention.
- BB administration failed to prevent or ameliorate the memory deficits induced by sleep deprivation.
- In non-sleep-deprived rats, BB administration before and after training, but not before testing, resulted in a retention deficit.
Conclusions:
- Bombesin (BB) does not counteract memory impairment caused by sleep deprivation.
- Under normal conditions, BB administration appears to impair memory consolidation.
- These findings suggest GRP modulation by BB is not a viable strategy to mitigate sleep deprivation-induced memory deficits.
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