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Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease

Akihiro Nomura, Hong-Hee Won, Amit V Khera

    Circulation Research
    |May 17, 2017
    PubMed
    Summary

    Protein-truncating variants (PTVs) in the cholesteryl ester transfer protein (CETP) gene are linked to improved lipid profiles and reduced coronary heart disease (CHD) risk. This genetic insight may inform future CETP inhibition therapies.

    Keywords:
    case-control studiescholesteryl ester transfer proteincoronary diseaselipids

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