Related Experiment Video For ANTICYCLIC CITRULLINATED ANTIBODIES
Updated: Mar 2, 2026
Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals
Published on: February 14, 2019
Anti-carbamylated Protein Antibodies Are Detectable in Various Connective Tissue Diseases
Shuichiro Nakabo1,2, Hajime Yoshifuji1,2, Motomu Hashimoto1,2
1From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan.
Objective:
Anti-carbamylated protein (anti-CarP) antibodies are possible diagnostic biomarkers of anticitrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA). We aimed to elucidate the prevalence of anti-CarP antibodies in non-RA connective tissue diseases (CTD) because CTD are important in the differential diagnosis of ACPA-negative RA.
Methods:
The sera from 266 patients with RA and 616 patients with CTD and 80 healthy controls were examined using an in-house anti-CarP ELISA.
Results:
The prevalence and the level of anti-CarP antibodies in several CTD were comparable to those in ACPA-negative RA.
Conclusion:
Anti-CarP antibodies are not useful for differentiating ACPA-negative RA from CTD.
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