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Salivary Immunoglobulin Gene Expression in Patients with Caries
Gema Regina Guadarrama Santín1, Angel Visoso Salgado1, Norma Margarita Montiel Bastida1
1Laboratory of Molecular Biology, Medical Sciences Research Center (CICMED), Autonomous University of the State of Mexico (UAEMex), Jesús Carranza 205, Col. Universidad, C.P. 50130, Toluca, México, Mexico.
Background:
Immunoglobulins mediate the host's humoral immune response are expressed in saliva.
Aim:
To quantify the FcαR, FcγRIIB, and FcαμR gene expression in the saliva of Mexican patients with caries in mixed and permanent dentition.
Subjects And Methods:
This was a comparative cross-sectional study. mRNA was isolated from 200 μL of saliva following the RNA III Tissue Fresh-frozen protocol of the MagNA Pure LC Instrument 2.0 (Roche Diagnostics GmbH, Nederland BV) and the FcαR, FcαμR and FcγRIIB were quantified through TaqMan Assays.
Results:
One hundred individuals, 50 with mixed dentition and 50 with permanent dentition, were included in the study. Statistically, it was found a significant difference (p = 0.025) in the IgG (FcγRIIB) expression between the studied groups.
Conclusion:
Although we confirmed the existence of FcαR, FcγRIIB and FcαμR gene expression in saliva, only a significant difference in the expression of FcγRIIB between the mixed dentition and permanent dentition was found.
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