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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
Amnion Membrane in Diabetic Foot Wounds: A Meta-analysis
Alexandra M Haugh1, Jacqueline G Witt1, Adam Hauch1
1Tulane University School of Medicine, New Orleans, La.; Department of Surgery, Tulane University School of Medicine, New Orleans, La.; Department of Economics, Tulane University, New Orleans, La.; Thayer School of Engineering, Dartmouth College, Hanover, N.H.; and Department of Plastic & Reconstructive Surgery, Weill Cornell Medical College/Houston Methodist Hospital, Houston, Tex.
Amniotic membrane treatments significantly improve healing rates for diabetic foot ulcers. This meta-analysis of randomized controlled trials shows a 2.75 times higher chance of healing with amniotic products compared to standard care.
Area of Science:
- Regenerative Medicine
- Wound Healing
- Biomaterials
Background:
- Amniotic membrane, derived from human placenta, is rich in healing factors.
- It possesses anti-infective, healing, and regenerative properties.
- These properties are beneficial for chronic wound management.
Purpose of the Study:
- To evaluate the efficacy of amniotic membrane products in treating diabetic foot ulcers.
- To compare amniotic tissue treatments against standard care through meta-analysis.
Main Methods:
- A systematic meta-analysis of randomized controlled trials was conducted.
- Searched databases included PubMed, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews.
- Five trials with a total of 311 patients were included.
Main Results:
- Amniotic membrane products demonstrated a significantly higher healing rate compared to standard care.
- The pooled relative risk for healing with amniotic products was 2.75 (P < 0.001).
- The analysis included 5 randomized controlled trials involving 311 patients.
Conclusions:
- Amniotic membrane treatment enhances healing rates for diabetic foot ulcers.
- Further research is required to assess the impact on reducing complications like amputation or mortality.
