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Published on: September 25, 2019
Amnion Membrane in Diabetic Foot Wounds: A Meta-analysis
Alexandra M Haugh1, Jacqueline G Witt1, Adam Hauch1
1Tulane University School of Medicine, New Orleans, La.; Department of Surgery, Tulane University School of Medicine, New Orleans, La.; Department of Economics, Tulane University, New Orleans, La.; Thayer School of Engineering, Dartmouth College, Hanover, N.H.; and Department of Plastic & Reconstructive Surgery, Weill Cornell Medical College/Houston Methodist Hospital, Houston, Tex.
Background:
Amniotic membrane is tissue obtained from human placenta rich in cytokines, growth factors, and stem cells that possess the ability to inhibit infection, improve healing, and stimulate regeneration.
Methods:
A meta-analysis was performed examining randomized controlled trials comparing amniotic tissue products with standard of care in nonhealing diabetic foot ulcers including PubMed, Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews.
Results:
A search of 3 databases identified 596 potentially relevant articles. Application of selection criteria led to the selection of 5 randomized controlled trials. The 5 selected randomized controlled trials represented a total of 311 patients. The pooled relative risk of healing with amniotic products compared with control was 2.7496 (2.05725-3.66524, P < 0.001).
Conclusions:
The current meta-analysis indicates that the treatment of diabetic foot ulcers with amniotic membrane improves healing rates in diabetic foot ulcers. Further studies are needed to determine whether these products also decrease the incidence of subsequent complications, such as amputation or death, in diabetic patients.
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