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Updated: Mar 2, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

18.7K

Pulse wave velocity measurement as a marker of arterial stiffness in pediatric inflammatory bowel disease: a pilot

Eberhard Lurz1,2, Eliane Aeschbacher1,3, Nicholas Carman2

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, University Children's Hospital, Inselspital, University of Bern, Bern, Switzerland.

European Journal of Pediatrics
|May 17, 2017
PubMed

Insights

Arterial stiffness (AS) is not elevated in children with inflammatory bowel disease (IBD) in remission. Pulse wave velocity (PWV) measurements suggest normal vascular health in pediatric IBD patients without cardiovascular disease signs.

Area of Science:

  • Pediatric Cardiology
  • Gastroenterology
  • Vascular Biology

Background:

  • Inflammatory bowel disease (IBD) is linked to increased cardiovascular event risk in adults.
  • Arterial stiffness (AS), measured by pulse wave velocity (PWV), is an early indicator of cardiovascular disease (CVD).
  • PWV measurement is a feasible method for assessing AS in pediatric populations.

Purpose of the Study:

  • To evaluate arterial stiffness (AS) in children and adolescents diagnosed with inflammatory bowel disease (IBD).
  • To determine if PWV measurements indicate increased AS in pediatric IBD patients.

Main Methods:

  • Prospective study involving 25 children and adolescents with IBD.
  • Carotid-femoral pulse wave velocity (PWVcf) was measured to assess arterial stiffness.
  • Patient data included disease status (remission/activity) and treatments (e.g., anti-TNFα).

Main Results:

  • Arterial stiffness (AS) was not found to be increased in the studied cohort of pediatric IBD patients.
  • No signs of cardiovascular disease, such as arterial hypertension, were present in the participants.
  • The majority of subjects (68%) were in clinical remission, and 48% were on anti-TNFα therapy.

Conclusions:

  • Pulse wave velocity (PWV) appears normal in children with IBD experiencing remission or mild disease activity.
  • Further research with larger studies is recommended to validate PWV as a non-invasive follow-up marker for children with IBD.
  • Early detection and monitoring via PWV could help prevent future cardiovascular complications in pediatric IBD patients.

Keywords:
Arterial stiffnessCardiovascular diseaseIBDInflammationPWVPulse wave velocity

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