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Related Concept Videos

Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

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Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
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GPCR Desensitization01:12

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G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
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Amplifying Signals via Enzymatic Cascade01:22

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When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
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IP3/DAG Signaling Pathway01:11

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Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
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MAPK Signaling Cascades01:07

MAPK Signaling Cascades

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Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
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Receptor Tyrosine Kinases01:26

Receptor Tyrosine Kinases

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Receptor tyrosine kinases or RTKs are membrane-bound receptors that phosphorylate specific tyrosine on protein substrates. RTKs regulate cellular growth, differentiation, survival, and migration. They contain an extracellular ligand binding domain, a transmembrane domain, and a cytosolic tail with intrinsic kinase activity. Several extracellular signaling molecules activate RTKs in one or more ways and relay the signal downstream. Ligands such as platelet-derived growth factor (PDGF) or...
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Related Experiment Video

Updated: Mar 2, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

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TRPC Channel Downstream Signaling Cascades.

Zhuohao He1

  • 1Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA. hezhuohao@gmail.com.

Advances in Experimental Medicine and Biology
|May 17, 2017
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential Canonical (TRPC) channels integrate external signals into cells. This review covers TRPC signaling molecules, their activation, and intracellular trafficking pathways.

Keywords:
Intracellular traffickingSignaling cascadesTRPC

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Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Ion Channels

Background:

  • Transient Receptor Potential (TRP) channels are crucial cation-permeable membrane proteins.
  • TRP channels act as cellular sensors, translating external stimuli into intracellular signals.
  • The TRPC (Transient Receptor Potential Canonical) subfamily represents the first identified mammalian TRP channels.

Purpose of the Study:

  • To review signaling molecules associated with TRPC channels.
  • To elucidate the upstream and downstream signaling cascades involving TRPC channels.
  • To explore the molecular mechanisms governing the intracellular trafficking of TRPC channels.

Main Methods:

  • Literature review of scientific publications on TRPC channels.
  • Analysis of signaling pathways and molecular interactions.
  • Synthesis of information on TRPC channel function and regulation.

Main Results:

  • TRPC channels are activated by diverse extracellular stimuli.
  • Specific signaling molecules initiate and modulate TRPC channel activity.
  • Intracellular trafficking pathways are critical for TRPC channel localization and function.

Conclusions:

  • TRPC channels are key integrators of cellular signaling.
  • Understanding TRPC signaling cascades is vital for deciphering cellular responses.
  • Further research into TRPC trafficking may reveal therapeutic targets.