Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

2.1K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.1K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

87.8K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
87.8K
Long-term Potentiation01:35

Long-term Potentiation

59.0K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
59.0K
Long-term Potentiation01:25

Long-term Potentiation

3.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.7K
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

13.8K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
13.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Excitatory synapses onto axonic spines jump-start action potentials and route information flow.

Nature neuroscience·2026
Same author

Optimized optogenetic anti-CRISPR for endogenous gene regulation in Drosophila.

Nucleic acids research·2026
Same author

BDNF insufficiency exacerbates ALS progression.

Cell reports. Medicine·2026
Same author

ADNP missense variant p.C687R disrupts chromatin regulation and GABAergic differentiation in Helsmoortel-Van der Aa syndrome.

Molecular autism·2026
Same author

Prefrontal chandelier cells encode stimulus salience to influence learning in male mice.

Nature communications·2026
Same author

Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus.

Nature communications·2025

Related Experiment Video

Updated: Mar 2, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

834

TRPC Channels and Neuron Development, Plasticity, and Activities.

Yilin Tai1, Yichang Jia2,3,4

  • 1Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY, 11724, USA.

Advances in Experimental Medicine and Biology
|May 17, 2017
PubMed
Summary

Transient Receptor Potential Canonical (TRPC) channels are crucial for brain development, influencing neuron growth, survival, and plasticity. Emerging research also highlights their roles in peripheral sensation and glial cell modulation.

Keywords:
DevelopmentNeuronPlasticityTRPC channels

More Related Videos

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

10.0K
Rapid Neuronal Differentiation of Induced Pluripotent Stem Cells for Measuring Network Activity on Micro-electrode Arrays
09:20

Rapid Neuronal Differentiation of Induced Pluripotent Stem Cells for Measuring Network Activity on Micro-electrode Arrays

Published on: January 8, 2017

28.1K

Related Experiment Videos

Last Updated: Mar 2, 2026

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

834
Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

10.0K
Rapid Neuronal Differentiation of Induced Pluripotent Stem Cells for Measuring Network Activity on Micro-electrode Arrays
09:20

Rapid Neuronal Differentiation of Induced Pluripotent Stem Cells for Measuring Network Activity on Micro-electrode Arrays

Published on: January 8, 2017

28.1K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Ion Channel Function

Background:

  • Transient Receptor Potential Canonical (TRPC) channels are a class of ion channels with diverse physiological roles.
  • Their involvement in the central and peripheral nervous systems is increasingly recognized.
  • TRPC channels are expressed in various neuronal and glial cell types.

Purpose of the Study:

  • To review the multifaceted functions of TRPC channels in mammalian brain development.
  • To explore the emerging roles of TRPC channels in peripheral nervous system functions, particularly sensation and nociception.
  • To consider the potential modulatory roles of TRPC channels in glial cells.

Main Methods:

  • Literature review and synthesis of existing research on TRPC channel functions.
  • Analysis of studies investigating TRPC channel involvement in neurogenesis, neuronal survival, and plasticity.
  • Examination of research on TRPC channels in dorsal root ganglion (DRG) and glial cells.

Main Results:

  • TRPC channels are integral to neural progenitor proliferation, neurogenesis, neuron survival, axon guidance, dendritic morphology, synaptogenesis, and neural plasticity.
  • TRPC channels play significant roles in peripheral sensation and nociception within the dorsal root ganglion (DRG).
  • Expression in glial cells suggests TRPC channels may modulate glial functions.

Conclusions:

  • TRPC channels are critical regulators of both central nervous system development and peripheral sensory functions.
  • Further research is needed to elucidate TRPC channel structures, cell-specific roles, and develop targeted modulators.
  • Understanding TRPC channel conformation changes is essential for future therapeutic strategies.