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Controlled Cortical Impact Model for Traumatic Brain Injury
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TRPC Channels and Brain Inflammation.

Yoshito Mizoguchi1, Akira Monji2

  • 1Department of Psychiatry, Faculty of Medicine, Saga University, Saga, Japan. ymizo@cc.saga-u.ac.jp.

Advances in Experimental Medicine and Biology
|May 17, 2017
PubMed
Summary

Chronic inflammation is linked to many diseases. Brain-derived neurotrophic factor (BDNF) affects microglial cells and calcium signaling, potentially impacting psychiatric disorders like depression.

Keywords:
BDNFDepressionInflammationMicrogliaTRPC3

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Area of Science:

  • Neuroscience
  • Immunology
  • Cell Biology

Background:

  • Nonresolving low-grade inflammation is implicated in chronic diseases, including cardiovascular diseases, cancer, diabetes, obesity, and psychiatric disorders.
  • Microglial cells mediate inflammatory responses in the brain, and their activation is linked to the pathophysiology of psychiatric disorders.
  • Intracellular calcium (Ca2+) signaling is crucial for microglial cell functions, and its alterations are implicated in psychiatric conditions like depression.

Purpose of the Study:

  • To investigate the role of Brain-Derived Neurotrophic Factor (BDNF) in microglial cell activation and calcium signaling.
  • To explore the involvement of Transient Receptor Potential Canonical 3 (TRPC3) channels in BDNF-induced microglial responses.
  • To understand the potential implications of BDNF-microglial interactions in the context of psychiatric disorders.

Main Methods:

  • Utilized rodent microglial cell models.
  • Investigated intracellular Ca2+ signaling pathways.
  • Examined the expression and function of TRPC3 channels in response to BDNF stimulation.

Main Results:

  • BDNF was shown to induce sustained intracellular Ca2+ elevation in microglial cells.
  • This effect was mediated by the upregulation of surface expression of TRPC3 channels.
  • Microglial cells demonstrate responsiveness to BDNF, suggesting a role in regulating inflammatory responses.

Conclusions:

  • BDNF signaling through TRPC3 channels influences microglial cell activity and calcium homeostasis.
  • These findings highlight a potential mechanism linking neuroinflammation and psychiatric disorders.
  • Further research on proBDNF and TRPC channels in microglial cells is warranted for understanding and treating psychiatric disorders.