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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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Gene polymorphisms associated with temperament.

Xiaoyan Qiu1,2, Graeme B Martin2,3, Dominique Blache2

  • 1a College of Animal Science and Technology, Southwest University , Chong Qing , PR China.

Journal of Neurogenetics
|May 17, 2017
PubMed
Summary
This summary is machine-generated.

Individual differences in stress response, known as temperament, are influenced by genetic factors. Gene variations in the hypothalamic-pituitary-adrenocortical (HPA) axis and neurotransmitter networks impact temperament, psychological disorders, and behavior.

Keywords:
HPA axisTemperamentgene polymorphismsneurotransmitter networks

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Area of Science:

  • Behavioral genetics
  • Neuroscience
  • Endocrinology

Background:

  • Individual responses to stress vary across psychological, behavioral, and physiological components.
  • Temperament describes this individual variability.
  • Growing evidence links temperament, personality, and disorders to genetic factors.

Purpose of the Study:

  • To review the impact of candidate gene polymorphisms on temperament, psychological disorders, and behavioral traits.
  • To explore genetic influences on the hypothalamic-pituitary-adrenocortical (HPA) axis and neurotransmitter systems.

Main Methods:

  • Review of existing literature on gene polymorphisms.
  • Focus on genes involved in corticotrophin-releasing hormone (CRH) and cortisol production (HPA axis).
  • Examination of polymorphisms in dopaminergic and serotonergic neurotransmitter networks.

Main Results:

  • Candidate gene polymorphisms probabilistically influence temperament, psychological disorders, and behavior in animals and humans.
  • Specific gene variations in the HPA axis and neurotransmitter systems are implicated.
  • Genetic factors play a significant role in individual differences in stress response.

Conclusions:

  • Understanding these genetic links can aid in diagnosing and treating human disorders.
  • This knowledge contributes to understanding animal evolution, welfare, and conservation.
  • Further research is needed on gene-gene and gene-environment interactions.