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Updated: Mar 2, 2026

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
Published on: June 24, 2015
Tonic regulation of stationary asynchronous firing of a neural network
1Lobachevsky State University of Nizhni Novgorod, Gagarin Avenue, 23, Nizhni Novgorod, 603950, Russia. denis.adamchik@gmail.com.
Abstract:
The impact of tonic conductance upon population activity was investigated. An extra tonic transmembrane current through GABA-activated extrasynaptic GABA A -receptors was found to control stationary asynchronous firing both quantitatively and qualitatively. Quantitative regulation consisted in alterating a current level of stationary population activity while qualitative regulation manifested itself in appearance of resilient asynchronous spiking in case GABA reversal potential exceeded a certain threshold. The study was based on a modified rate model after Wilson and Cowan and backed up with a computer simulation of an explicit network model.
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